Genetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?
نویسندگان
چکیده
منابع مشابه
A Rule Extractor for Diagnosing the Type 2 Diabetes Using a Self-organizing Genetic Algorithm
Introduction: Constructing medical decision support models to automatically extract knowledge from data helps physicians in early diagnosis of disease. Interpretability of the inferential rules of these models is a key indicator in determining their performance in order to understand how they make decisions, and increase the reliability of their output. Methods: In this study, an automated hyb...
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Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined. We conducted a multistage, genome-wide association study (GWAS) within the...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2012
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2012.08.002